Sexual dimorphism and the effects of the X-linked Tfm locus on hexobarbitone metabolism and action in mice.
Br J Pharmacol
; 74(1): 97-104, 1981 Sep.
Article
en En
| MEDLINE
| ID: mdl-7196788
ABSTRACT
1 Normal males of the testicular feminized strain of mice (Tfm) had longer hexobarbitone-induced sleeping times than females, and hepatic hexobarbitone hydroxylase activity different in that the Km was higher and the Vmax lower in the male. 2 Castration and androgen replacement studies indicated that testicular androgens were responsible for the sexual differences in drug metabolism found in this mouse strain. 3 Hepatic hexobarbitone metabolism and action were feminized in the intact, androgen-insensitive, genetically male Tfm mouse. Furthermore, hexobarbitone hydroxylase activities were less responsive to large doses of testosterone in Tfm mice than in normal males. 4 The Tfm mouse with a deficiency in androgen receptors responded to the enzyme-inductive effects of phenobarbitone and softwood bedding, indicating that these inducers do not act through the androgen receptors.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Síndrome de Resistencia Androgénica
/
Hexobarbital
Límite:
Animals
Idioma:
En
Revista:
Br J Pharmacol
Año:
1981
Tipo del documento:
Article