Ultrastructural studies of allergic contact dermatitis in man. Epidermal cell changes at 3, 6, and 12 h after application of DNCB.
Arch Dermatol Res
; 267(3): 275-82, 1980.
Article
en En
| MEDLINE
| ID: mdl-7406537
ABSTRACT
Early epidermal lesions of allergic contact dermatitis were examined by electron microscopy. Normal human volunteers were sensitized to DNCB, and contact reactions were elicited sequentially. Epidermal cell changes at 3 h included the occurrence of small vacuoles with or without membrane, focal dilatation of intercellular spaces, and the alteration of tonofilaments into short, aggregated bundles. Non-sensitized skin to which DNCB was applied also showed small vacuoles with or without membrane. Monocytes infiltrated into the intercellular spaces which were not dilated, and the neighboring tonofilaments of keratinocytes remained normal.
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Bases de datos:
MEDLINE
Asunto principal:
Dermatitis por Contacto
/
Epidermis
Tipo de estudio:
Etiology_studies
Límite:
Adolescent
/
Adult
/
Humans
/
Male
Idioma:
En
Revista:
Arch Dermatol Res
Año:
1980
Tipo del documento:
Article