Specific inhibition of vascular cell adhesion molecule-1 expression by type IV collagen in endothelial cells.
Biochem Biophys Res Commun
; 214(3): 1163-7, 1995 Sep 25.
Article
en En
| MEDLINE
| ID: mdl-7575525
ABSTRACT
The effects of matrices on the expression of adhesion molecules were studied in cultured human umbilical cord vein endothelial cells(HUVEC). The expression of vascular cell adhesion molecule-1 (VCAM-1) but not of intercellular adhesion molecule-1 stimulated with various substances was remarkably low in HUVEC cultured on type IV collagen, the major component of the basement membrane, compared with that on type I collagen. This inhibition was observed not only at the protein level but also at the mRNA level. These data suggested that VCAM-1 expression in endothelial cells is strictly regulated by the underlying basement membrane.
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Bases de datos:
MEDLINE
Asunto principal:
Endotelio Vascular
/
Expresión Génica
/
Colágeno
/
Molécula 1 de Adhesión Celular Vascular
Límite:
Humans
Idioma:
En
Revista:
Biochem Biophys Res Commun
Año:
1995
Tipo del documento:
Article
País de afiliación:
Japón