Human immunodeficiency virus type 1-infected cells in breast milk: association with immunosuppression and vitamin A deficiency.
J Infect Dis
; 172(6): 1461-8, 1995 Dec.
Article
en En
| MEDLINE
| ID: mdl-7594703
ABSTRACT
Breast milk samples from human immunodeficiency virus type 1 (HIV-1)-seropositive women were analyzed by polymerase chain reaction to determine the prevalence and determinants of HIV-1-infected cells in breast milk. Breast milk samples (212) were collected from 107 women, and 58% of the samples had detectable HIV-1 DNA. The proportion of HIV-1-infected cells in the milk samples ranged from 1 to 3255/10(4) cells. Breast milk samples with detectable HIV-1 DNA were more likely to be from women with absolute CD4 cell counts of < 400 (odds ratio, 3.1; 95% confidence interval [CI], 1.5-7.0). Severe vitamin A deficiency (< 20 micrograms/dL) was associated with a 20-fold increased risk of having HIV-1 DNA in breast milk among women with < 400 CD4 cells/mm3 (95% CI, 2.1-188.5). Women with CD4 cell depletion, especially those with vitamin A deficiency, may be at increased risk of transmitting HIV-1 to their infants through breast milk.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Deficiencia de Vitamina A
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VIH-1
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Transmisión Vertical de Enfermedad Infecciosa
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Tolerancia Inmunológica
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Leche Humana
Tipo de estudio:
Clinical_trials
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Risk_factors_studies
Límite:
Adolescent
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Adult
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Female
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Humans
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Pregnancy
Idioma:
En
Revista:
J Infect Dis
Año:
1995
Tipo del documento:
Article
País de afiliación:
Kenia