Increased levels of plasma von Willebrand factor in migraine crisis.
Acta Neurol Scand
; 91(5): 412-3, 1995 May.
Article
en En
| MEDLINE
| ID: mdl-7639074
ABSTRACT
INTRODUCTION:
To evaluate the participation of the vessel wall in the pathogenesis of migraine attack, we measured the plasma levels of von Willebrand factor (vWF), a protein secreted from the endothelial cells. MATERIAL &METHODS:
17 patients suffering from migraine without aura and 25 healthy volunteers were studied. von Willebrand factor and platelet aggregation tests were studied by conventional methods.RESULTS:
The levels of vWFantigen increased from 72.4 +/- 29 U/dl in the intercrisis to 130.2 +/- 75 U/dl during the attack (p < 0.01). We did not detect difference in the platelet aggregability in both phases. Plasma vWF activity measured as ristocetin cofactor (vWFRCo) was similar in intercrisis and crisis (100.6 +/- 31 U/dl vs 94.5 +/- 44 U/dl).CONCLUSIONS:
There is a plasma release of vWF molecules during the migraine crisis. This feature is not platelet dependent and is probably a consequence of endothelial stress.
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Bases de datos:
MEDLINE
Asunto principal:
Factor de von Willebrand
/
Trastornos Migrañosos
Límite:
Adolescent
/
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Acta Neurol Scand
Año:
1995
Tipo del documento:
Article
País de afiliación:
España