Strain-dependent variability in nitrous oxide withdrawal seizure frequency.
Life Sci
; 57(11): 1125-30, 1995.
Article
en En
| MEDLINE
| ID: mdl-7658919
ABSTRACT
Exposure to nitrous oxide produces handling induced convulsions following withdrawal in mice. Since strain differences in responsiveness to the antinociceptive potency of N2O have been found, we examined whether there were differences in susceptibility to N2O withdrawal seizures. Significant differences were found between mouse strains, varying between 100% and 0% of mice exhibiting withdrawal seizures. There was a lack of correlation between the sensitivity of the mouse strains to N2O-induced analgesia and N2O withdrawal seizures, suggesting different mechanisms of action.
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Bases de datos:
MEDLINE
Asunto principal:
Convulsiones
/
Óxido Nitroso
Límite:
Animals
Idioma:
En
Revista:
Life Sci
Año:
1995
Tipo del documento:
Article
País de afiliación:
Estados Unidos