Apolipoprotein E epsilon 4 allele frequency is not increased in progressive supranuclear palsy.
Neurology
; 45(9): 1764-5, 1995 Sep.
Article
en En
| MEDLINE
| ID: mdl-7675243
ABSTRACT
We examined apolipoprotein E (ApoE) immunoreactivity and allele frequency in 12 autopsied cases of progressive supranuclear palsy (PSP), a neurodegenerative disease characterized by diffuse neurofibrillary tangle (NFT) formation without beta-amyloid deposits. In spite of the ApoE immunoreactivity associated with NFTs, in PSP the ApoE allele frequency was comparable with that of age-matched normal controls. This suggests that in Alzheimer's disease the increased frequency of ApoE epsilon 4 does not influence neurofibrillary degeneration, but is probably linked to beta-amyloid deposition.
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Bases de datos:
MEDLINE
Asunto principal:
Apolipoproteínas E
/
Parálisis Supranuclear Progresiva
/
Alelos
Límite:
Humans
Idioma:
En
Revista:
Neurology
Año:
1995
Tipo del documento:
Article
País de afiliación:
Italia