Your browser doesn't support javascript.
loading
Preferential migration of activated CD4+ and CD8+ T cells in response to MIP-1 alpha and MIP-1 beta.
Taub, D D; Conlon, K; Lloyd, A R; Oppenheim, J J; Kelvin, D J.
Afiliación
  • Taub DD; Laboratory of Molecular Immunoregulation, National Cancer Institute, Frederick Cancer Research and Development Center (FCRDC), MD 21702.
Science ; 260(5106): 355-8, 1993 Apr 16.
Article en En | MEDLINE | ID: mdl-7682337
Recombinant human macrophage inflammatory protein-1 alpha (rhMIP-1 alpha) and rhMIP-1 beta were potent chemoattractants of human T lymphocytes. These rhMIP-1 cytokines attracted only T cells activated by monoclonal antibody to CD3 and did not attract unstimulated lymphocytes. Phenotypic analysis revealed that CD4+ T cells were capable of migrating in response to rhMIP-1 beta, whereas rhMIP-1 alpha induced chemotaxis of predominantly CD8+ T lymphocytes. Activated naïve and memory T cells also migrated in response to rhMIP-1 cytokines. Furthermore, these cytokines enhanced the ability of T cells to bind to an endothelial cell monolayer. These results suggest that rhMIP-1 cytokines preferentially recruit specific T cell subsets during the evolution of the immune response.
Asunto(s)
Buscar en Google
Bases de datos: MEDLINE Asunto principal: Activación de Linfocitos / Linfocitos T Citotóxicos / Linfocitos T CD4-Positivos / Quimiotaxis de Leucocito / Citocinas / Monocinas / Linfocitos T Reguladores Límite: Adult / Humans Idioma: En Revista: Science Año: 1993 Tipo del documento: Article
Buscar en Google
Bases de datos: MEDLINE Asunto principal: Activación de Linfocitos / Linfocitos T Citotóxicos / Linfocitos T CD4-Positivos / Quimiotaxis de Leucocito / Citocinas / Monocinas / Linfocitos T Reguladores Límite: Adult / Humans Idioma: En Revista: Science Año: 1993 Tipo del documento: Article