Preferential migration of activated CD4+ and CD8+ T cells in response to MIP-1 alpha and MIP-1 beta.
Science
; 260(5106): 355-8, 1993 Apr 16.
Article
en En
| MEDLINE
| ID: mdl-7682337
Recombinant human macrophage inflammatory protein-1 alpha (rhMIP-1 alpha) and rhMIP-1 beta were potent chemoattractants of human T lymphocytes. These rhMIP-1 cytokines attracted only T cells activated by monoclonal antibody to CD3 and did not attract unstimulated lymphocytes. Phenotypic analysis revealed that CD4+ T cells were capable of migrating in response to rhMIP-1 beta, whereas rhMIP-1 alpha induced chemotaxis of predominantly CD8+ T lymphocytes. Activated naïve and memory T cells also migrated in response to rhMIP-1 cytokines. Furthermore, these cytokines enhanced the ability of T cells to bind to an endothelial cell monolayer. These results suggest that rhMIP-1 cytokines preferentially recruit specific T cell subsets during the evolution of the immune response.
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Bases de datos:
MEDLINE
Asunto principal:
Activación de Linfocitos
/
Linfocitos T Citotóxicos
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Linfocitos T CD4-Positivos
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Quimiotaxis de Leucocito
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Citocinas
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Monocinas
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Linfocitos T Reguladores
Límite:
Adult
/
Humans
Idioma:
En
Revista:
Science
Año:
1993
Tipo del documento:
Article