Cytogenetic effects of benzimidazoles in mouse bone marrow.
Mutat Res
; 300(1): 15-28, 1993 Jun.
Article
en En
| MEDLINE
| ID: mdl-7683764
ABSTRACT
The cytogenetic effects of three benzimidazoles, i.e., benomyl, methyl thiophanate and methyl 2-benzimidazolecarbamate (MBC), were studied in mouse bone marrow cells by analyzing three genetic endpoints micronuclei, structural chromosome aberrations plus or minus gaps, and aneugenic effects (hyperdiploidy or polyploidy). In general, the effects were small, but it was observed that benomyl and MBC significantly induced micronuclei as well as aneugenic effects, hyperdiploidy (no metaphases with more than one or two extra chromosomes, 2n + 1 or 2n + 2, were observed) and polyploidy (4n). The induction of chromosome gaps and breaks was less evident. Methyl thiophanate significantly induced micronuclei, but it was less effective than benomyl and MBC. Our results showed that micronuclei are a good indicator of aneugenic effects in mouse bone marrow cells. A curvilinear trend test has been devised to fit the curves originating from the time-dependent responses.
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Bases de datos:
MEDLINE
Asunto principal:
Bencimidazoles
/
Médula Ósea
/
Carbamatos
/
Aberraciones Cromosómicas
/
Mutágenos
Tipo de estudio:
Diagnostic_studies
Límite:
Animals
Idioma:
En
Revista:
Mutat Res
Año:
1993
Tipo del documento:
Article
País de afiliación:
Italia