A bioactive fullerene peptide.
J Med Chem
; 37(26): 4558-62, 1994 Dec 23.
Article
en En
| MEDLINE
| ID: mdl-7799406
ABSTRACT
The highly hydrophobic C60 (buckminsterfullerene) was water solubilized by covalently linking the synthon 1,2-dihydro-1,2-methanofullerene [60]-61-carboxylic acid to the alpha-amino group of the hydrophilic 4-8 sequence of peptide T, known to display potent human monocyte chemotaxis. The resulting compound, characterized by a variety of analytical techniques, including a UV spectrum in aqueous solution, exhibits remarkable chemotactic potency, comparable to that of the parent pentapeptide. Furthermore, this fullerene-peptide conjugate inhibits, albeit weakly, HIV-1 protease.
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Bases de datos:
MEDLINE
Asunto principal:
Péptido T
Límite:
Humans
Idioma:
En
Revista:
J Med Chem
Asunto de la revista:
QUIMICA
Año:
1994
Tipo del documento:
Article
País de afiliación:
Italia