Enhancement of the mutagenicity of amino acid pyrolysates by phthalate esters.
Environ Mol Mutagen
; 24(4): 325-31, 1994.
Article
en En
| MEDLINE
| ID: mdl-7851345
ABSTRACT
The ability of phthalic acid, phthalic acid anhydride, and various phthalate esters to enhance the mutagenicity of many amino acid pyrolysates was observed with the Ames test (Salmonella typhimurium TA98), but not the SOS Chromotest. Phthalate enhancement of the mutagenicity of 4-nitroquinoline-1-oxide, 2-nitrofluorene, and benzo[a]pyrene was not observed with either test. The mutagenicity-enhancing ability may be related to the induction of enzymes such as P450IIB, that metabolize amino acid pyrolysates. By quantitative structure activity relationship (QSAR) analysis, a good correlation was observed between the mutagenicity-enhancing activity of phthalates and their octanol-water partition coefficients.
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Bases de datos:
MEDLINE
Asunto principal:
Ácidos Ftálicos
/
Carbolinas
/
Mutagénesis
/
Mutágenos
Idioma:
En
Revista:
Environ Mol Mutagen
Asunto de la revista:
BIOLOGIA MOLECULAR
/
SAUDE AMBIENTAL
Año:
1994
Tipo del documento:
Article
País de afiliación:
Japón