Catalytic antibodies: a critical assessment.
Mol Biotechnol
; 1(1): 87-103, 1994 Feb.
Article
en En
| MEDLINE
| ID: mdl-7859154
ABSTRACT
In the past few years, antibodies that catalyze a variety of reactions with enzyme-like properties have been produced. The present review is of a critical nature, rather than a survey or an introduction to the field of catalytic antibodies. Here, we examine the performance of catalytic antibodies in light of the features that define an enzyme substrate specificity, rate enhancement, and turnover. We also refer to some limitations of the technologies currently used for their generation. In the future, antibodies may provide a new repertoire of tailor-made, enzyme-like, catalysts with possible applications in biology, medicine, and biotechnology. In the following sections, we emphasize that these applications will require far more efficient catalysts than are presently available, and we point to several trends for future research that may offer more efficient catalytic antibodies.
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Bases de datos:
MEDLINE
Asunto principal:
Anticuerpos Catalíticos
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Mol Biotechnol
Asunto de la revista:
BIOLOGIA MOLECULAR
/
BIOTECNOLOGIA
Año:
1994
Tipo del documento:
Article
País de afiliación:
Israel