Impairment in mitochondrial cytochrome oxidase gene expression in Alzheimer disease.
Brain Res Mol Brain Res
; 24(1-4): 336-40, 1994 Jul.
Article
en En
| MEDLINE
| ID: mdl-7968373
ABSTRACT
Brains from 5 patients with Alzheimer's disease (AD) showed a 50%-65% decrease in mRNA levels of the mitochondrial-encoded cytochrome oxidase (COX, a marker of oxidative metabolism) subunits I and III in the middle temporal association neocortex, but not in the primary motor cortex, as compared to 5 control brains. The amount of mitochondrial-encoded 12S rRNA was not altered, nor was the amount of nuclear-encoded lactate dehydrogenase B mRNA (a marker of glycolytic metabolism). These data suggest that the decrease in COX I and III subunits mRNA in affected brain regions may contribute to reduced brain oxidative metabolism in AD.
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Bases de datos:
MEDLINE
Asunto principal:
Encéfalo
/
Expresión Génica
/
Complejo IV de Transporte de Electrones
/
Enfermedad de Alzheimer
/
Mitocondrias
Tipo de estudio:
Clinical_trials
Límite:
Aged
/
Aged80
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
Brain Res Mol Brain Res
Asunto de la revista:
BIOLOGIA MOLECULAR
/
CEREBRO
Año:
1994
Tipo del documento:
Article