Inhibition of NF-kappa B by sodium salicylate and aspirin.
Science
; 265(5174): 956-9, 1994 Aug 12.
Article
en En
| MEDLINE
| ID: mdl-8052854
ABSTRACT
The transcription factor nuclear factor-kappa B (NF-kappa B) is critical for the inducible expression of multiple cellular and viral genes involved in inflammation and infection including interleukin-1 (IL-1), IL-6, and adhesion molecules. The anti-inflammatory drugs sodium salicylate and aspirin inhibited the activation of NF-kappa B, which further explains the mechanism of action of these drugs. This inhibition prevented the degradation of the NF-kappa B inhibitor, I kappa B, and therefore NF-kappa B was retained in the cytosol. Sodium salicylate and aspirin also inhibited NF-kappa B-dependent transcription from the Ig kappa enhancer and the human immunodeficiency virus (HIV) long terminal repeat (LTR) in transfected T cells.
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Bases de datos:
MEDLINE
Asunto principal:
Factores de Transcripción
/
Salicilato de Sodio
/
Aspirina
/
FN-kappa B
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Science
Año:
1994
Tipo del documento:
Article