Effect of policosanol on experimental thrombosis models.
Prostaglandins Leukot Essent Fatty Acids
; 50(5): 249-51, 1994 May.
Article
en En
| MEDLINE
| ID: mdl-8066100
ABSTRACT
Policosanol is a natural product, obtained from sugar cane wax (Saccharum officinarum L.) with which cholesterol-lowering effects have been demonstrated in experimental models, healthy volunteers and hypercholesterolemic patients. The effects of policosanol on experimental venous and arterial thrombosis in rats were investigated. Policosanol (25 mg/kg) significantly decreased the thrombus weight, in the venous thrombosis models, the protective effect persisting until 4 h after its oral administration. Policosanol (25 mg/kg single dose) was able to reduce rectal temperature variation induced by arterial thrombosis. Also at the same dose policosanol increased 6-keto-PGF1 alpha serum levels in rats.
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Bases de datos:
MEDLINE
Asunto principal:
Trombosis
/
Alcoholes Grasos
/
Anticolesterolemiantes
Tipo de estudio:
Clinical_trials
Límite:
Animals
/
Female
/
Humans
Idioma:
En
Revista:
Prostaglandins Leukot Essent Fatty Acids
Asunto de la revista:
ENDOCRINOLOGIA
Año:
1994
Tipo del documento:
Article
País de afiliación:
Cuba