Familial male breast cancer is not linked to the BRCA1 locus on chromosome 17q.
Nat Genet
; 7(1): 103-7, 1994 May.
Article
en En
| MEDLINE
| ID: mdl-8075631
ABSTRACT
Breast cancer in men is about a hundredfold less common than in women and this has hindered research into its genetic basis. We have examined 22 families with at least one case of male breast cancer for linkage to the hereditary breast and ovarian cancer locus, BRCA1, on chromosome 17q. We found strong evidence against linkage to BRCA1 (lod score-16.63) and the best estimate of the proportion of linked families was 0% (95% CI 0-18%). Our results indicate that there is a gene(s) other than BRCA1 which predisposes to early-onset breast cancer in women and which confers a higher risk of male breast cancer. Identification of additional pedigrees that include cases of male breast cancer may therefore facilitate the mapping and isolation of this gene.
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Bases de datos:
MEDLINE
Asunto principal:
Cromosomas Humanos Par 17
/
Neoplasias de la Mama
Tipo de estudio:
Etiology_studies
/
Prognostic_studies
/
Risk_factors_studies
Límite:
Female
/
Humans
/
Male
Idioma:
En
Revista:
Nat Genet
Asunto de la revista:
GENETICA MEDICA
Año:
1994
Tipo del documento:
Article
País de afiliación:
Reino Unido