bendless, a Drosophila gene affecting neuronal connectivity, encodes a ubiquitin-conjugating enzyme homolog.
J Neurosci
; 14(5 Pt 2): 3166-79, 1994 May.
Article
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| MEDLINE
| ID: mdl-8182464
ABSTRACT
The Drosophila bendless (ben) gene was originally isolated as a mutation affecting the escape jump response. This behavioral defect was ascribed to a single lesion affecting the connectivity between the giant fiber and the tergotrochanter motor neuron. A closer examination of the ben phenotype suggests that ben activity is broader and affects a variety of other neurons including photoreceptor cells and their axons. Mosaic analysis indicates that the focus of ben activity is presynaptic. We have cloned the ben gene through a chromosomal walk and show that it is homologous to a class of ubiquitin-conjugating enzymes. The major role of ubiquitination in the protein degradative pathway suggests that ben regulates neural developmental processes such as growth cone guidance by targeting specific proteins for degradation.
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Bases de datos:
MEDLINE
Asunto principal:
Ubiquitinas
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Drosophila
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Reacción de Fuga
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Neuronas
Límite:
Animals
Idioma:
En
Revista:
J Neurosci
Año:
1994
Tipo del documento:
Article