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Epidermal growth factor receptor expression in squamous cell carcinoma of the hypopharynx.
Frank, J L; Garb, J L; Banson, B B; Peterman, J; Neifeld, J P; Kay, S; Kornstein, M J; Sismanis, A; Ware, J L.
Afiliación
  • Frank JL; Department of Surgery, Baystate Medical Center, Tufts University School of Medicine, Springfield, MA 01199.
Surg Oncol ; 2(3): 161-7, 1993.
Article en En | MEDLINE | ID: mdl-8252205
Expression of the epidermal growth factor receptor (EGFR) has been demonstrated in normal and malignant squamous epithelia. Its presence has been suggested to be important in the pathophysiology and prognosis of epithelial cancers. Archival tumour specimens from 57 patients with squamous cell carcinoma of the hypopharynx were studied using OM-11-951, a new murine anti-EGFR monoclonal antibody which recognizes the receptor on deparaffinized tissue. By visual inspection, 28 (49%) tumours were EGFR negative; 29 (51%) tumours were EGFR positive. While patients whose tumours were EGFR positive were younger, there was no significant correlation with other clinical or pathological variables (including grade and stage). Patients whose tumours were EGFR negative had a median survival of 21 (95% CI 4.3-37.7) months compared with a median survival of 17 (95% CI 11.4-22) months for patients whose tumours were EGFR positive. The difference was not statistically significant. A multiple regression analysis did not demonstrate EGFR status to be important in predicting survival. These data cast doubt on the prognostic significance of EGFR expression in this neoplasm.
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Bases de datos: MEDLINE Asunto principal: Carcinoma de Células Escamosas / Neoplasias Hipofaríngeas / Receptores ErbB Tipo de estudio: Prognostic_studies Límite: Female / Humans / Male / Middle aged Idioma: En Revista: Surg Oncol Asunto de la revista: NEOPLASIAS Año: 1993 Tipo del documento: Article
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Bases de datos: MEDLINE Asunto principal: Carcinoma de Células Escamosas / Neoplasias Hipofaríngeas / Receptores ErbB Tipo de estudio: Prognostic_studies Límite: Female / Humans / Male / Middle aged Idioma: En Revista: Surg Oncol Asunto de la revista: NEOPLASIAS Año: 1993 Tipo del documento: Article