A collagen receptor on Staphylococcus aureus strains isolated from patients with septic arthritis mediates adhesion to cartilage.
Mol Microbiol
; 7(1): 99-107, 1993 Jan.
Article
en En
| MEDLINE
| ID: mdl-8382334
ABSTRACT
Staphylococcus aureus strains isolated from patients with septic arthritis or osteomyelitis possess a collagen receptor present in two forms, which contains either two or three copies of a 187-amino-acid repeat motif. Collagen receptor-positive strains adhered to both collagen substrata and cartilage in a time-dependent process. Collagen receptor-specific antibodies blocked bacterial adherence, as did preincubation of the substrate with a recombinant form of the receptor protein. Furthermore, polystyrene beads coated with the collagen receptor bound collagen and attached to cartilage. Taken together, these results suggest that the collagen receptor is both necessary and sufficient to mediate bacterial adherence to cartilage in a process that constitutes an important part of the pathogenic mechanism in septic arthritis.
Buscar en Google
Bases de datos:
MEDLINE
Asunto principal:
Osteomielitis
/
Infecciones Estafilocócicas
/
Staphylococcus aureus
/
Adhesión Bacteriana
/
Artritis Infecciosa
/
Cartílago Articular
/
Colágeno
/
Receptores de Superficie Celular
Límite:
Humans
Idioma:
En
Revista:
Mol Microbiol
Asunto de la revista:
BIOLOGIA MOLECULAR
/
MICROBIOLOGIA
Año:
1993
Tipo del documento:
Article