Inhibitory effects of triptogelin A-1 on 12-O-tetradecanoylphorbol-13- acetate-induced skin tumor promotion.
Cancer Lett
; 68(2-3): 129-33, 1993 Feb.
Article
en En
| MEDLINE
| ID: mdl-8383000
ABSTRACT
Dihydroagarofuran sesquiterpenes, which were isolated from Tripterygium wilfordii Hook fil. var. regelii Makino and Euonymus sieboldianus Blume, showed inhibitory effects on Epstein-Barr virus early antigen (EBV-EA) activation induced by 12-O-tetradecanoylphorbol-13-acetate (TPA). Triptogelin A-1, one of the active dihydroagarofuran sesquiterpenes, exhibited remarkable inhibitory effects on mouse skin tumor promotion in an in vivo two-stage carcinogenesis test. Interestingly, triptogelin A-1 was more effective when applied after TPA-treatment (post-treatment) than before TPA-treatment (pretreatment). The findings indicate that these dihydroagarofuran sesquiterpenes might be valuable antitumor promoters.
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Bases de datos:
MEDLINE
Asunto principal:
Sesquiterpenos
/
Neoplasias Cutáneas
/
Compuestos Bicíclicos con Puentes
/
Acetato de Tetradecanoilforbol
Límite:
Animals
Idioma:
En
Revista:
Cancer Lett
Año:
1993
Tipo del documento:
Article
País de afiliación:
Japón