Characterization of the chicken and quail homologues of the human gene responsible for the X-linked Kallmann syndrome.
Genomics
; 17(2): 516-8, 1993 Aug.
Article
en En
| MEDLINE
| ID: mdl-8406507
ABSTRACT
The human KAL gene, responsible for the X-linked Kallmann syndrome, was isolated previously. Southern blot analysis using human cDNA probes detected cross-hybridization with DNA from several organisms, including chicken and quail. The entire coding sequences of chicken and quail KAL cDNAs were determined. A comparison of these cDNAs with the human KAL cDNA reveals an overall identity of 73 and 72%, respectively. This results in 76 and 75% identity at the protein level. The highest conservation was found in the WAP four-disulfide core motif and in two of the four fibronectin type III repeats reported in the human protein. These results further support the hypothesis that the KAL protein is an extracellular matrix component with anti-protease and adhesion functions.
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Bases de datos:
MEDLINE
Asunto principal:
Codorniz
/
Cromosoma X
/
Hominidae
/
Pollos
/
Síndrome de Kallmann
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Genomics
Asunto de la revista:
GENETICA
Año:
1993
Tipo del documento:
Article
País de afiliación:
Francia