Clues to the pathogenesis of familial colorectal cancer.
Science
; 260(5109): 812-6, 1993 May 07.
Article
en En
| MEDLINE
| ID: mdl-8484121
ABSTRACT
A predisposition to colorectal cancer is shown to be linked to markers on chromosome 2 in some families. Molecular features of "familial" cancers were compared with those of sporadic colon cancers. Neither the familial nor sporadic cancers showed loss of heterozygosity for chromosome 2 markers, and the incidence of mutations in KRAS, P53, and APC was similar in the two groups of tumors. Most of the familial cancers, however, had widespread alterations in short repeated DNA sequences, suggesting that numerous replication errors had occurred during tumor development. Thirteen percent of sporadic cancers had identical abnormalities and these cancers shared biologic properties with the familial cases. These data suggest a mechanism for familial tumorigenesis different from that mediated by classic tumor suppressor genes.
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Bases de datos:
MEDLINE
Asunto principal:
Cromosomas Humanos Par 2
/
Neoplasias Colorrectales
/
Neoplasias del Colon
Tipo de estudio:
Etiology_studies
Límite:
Female
/
Humans
/
Male
Idioma:
En
Revista:
Science
Año:
1993
Tipo del documento:
Article
País de afiliación:
Finlandia