Up-regulation of Bcl-2 is associated with neuronal DNA damage in Alzheimer's disease.
Neuroreport
; 7(2): 437-40, 1996 Jan 31.
Article
en En
| MEDLINE
| ID: mdl-8730800
ABSTRACT
Cell death and neurofibrillary tangle formation are prominent features of Alzheimer's disease (AD). It has been suggested that DNA damage may reflect neuronal vulnerability. In this context, the Ced homologue Bcl-2 is able to repress a number of cell death programs. Recently we found both numerous nuclei exhibiting DNA damage within neurons in the AD brain and increases in Bcl-2 immunoreactivity. In this study, we examined the relationship between Bcl-2 expression and nuclear DNA damage or tangle formation. Nuclei exhibiting DNA damage were associated with an up-regulation of Bcl-2 expression, whereas tangle-bearing neurons were associated with a down-regulation of Bcl-2 expression.
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Bases de datos:
MEDLINE
Asunto principal:
Daño del ADN
/
Regulación hacia Arriba
/
Proteínas Proto-Oncogénicas c-bcl-2
/
Enfermedad de Alzheimer
/
Neuronas
Tipo de estudio:
Risk_factors_studies
Límite:
Aged
/
Humans
Idioma:
En
Revista:
Neuroreport
Asunto de la revista:
NEUROLOGIA
Año:
1996
Tipo del documento:
Article
País de afiliación:
Estados Unidos