Suppressor cells in tolerance to contact sensitivity active against hapten-syngeneic and hapten-allogeneic determinants.
J Exp Med
; 146(1): 49-58, 1977 Jul 01.
Article
en En
| MEDLINE
| ID: mdl-874422
ABSTRACT
Genetic restrictions in generation and expression of hapten-specific suppressor cells for contact sensitivity were found. Dinitrophenol- (DNP) or trinitrophenol-modified mouse spleen cells (SC) induced suppressors in donors able to transfer suppression to normal recipients. When allogeneic DNP-SC were injected into BALB/c mice, cells were generated which were suppressive only in the allogeneic strain providing the DNP-SC. In contrast, when DNP-BALB/c-SC were injected into BALB/c mice, suppressors were generated which were active both in BALB/c and in allogeneic mice (e.g., CBA). This apparent absence of syngeneic major histocompability complex restriction may be explained by cross reactive T-cell receptors which are VH gene products.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Bazo
/
Supresión Genética
/
Dermatitis por Contacto
/
Haptenos
/
Histocompatibilidad
Tipo de estudio:
Diagnostic_studies
Límite:
Animals
Idioma:
En
Revista:
J Exp Med
Año:
1977
Tipo del documento:
Article