A novel arylsulfatase A protein variant and genotype in two patients with major depression.
J Affect Disord
; 40(3): 137-47, 1996 Oct 14.
Article
en En
| MEDLINE
| ID: mdl-8897113
ABSTRACT
A new, 'diffuse, multiple banding', electrophoretic variant of arylsulfatase A protein was found in two patients with major depression. Protein analyses showed that this variant and the normal enzyme differed in amino acid sequence and/or post-translational modifications unrelated to phosphate groups and oligomannose glycans. Analysis of the arylsulfatase A genes from a subject with the new variant identified three mutations; one gene had the two mutations associated with arylsulfatase A pseudodeficiency, and the other had a G to T transversion which changes a tryptophan to cysteine in the protein. These mutations result in an arylsulfatase A protein heteromer with diffuse electrophoretic banding. The possible association of these mutations with major depression is discussed.
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Bases de datos:
MEDLINE
Asunto principal:
Cerebrósido Sulfatasa
/
Trastorno Depresivo
/
Isoenzimas
Tipo de estudio:
Diagnostic_studies
/
Prognostic_studies
Límite:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
J Affect Disord
Año:
1996
Tipo del documento:
Article
País de afiliación:
Estados Unidos