Pharmacokinetics of a new nitroderivative of acetylsalicylic acid after a single dose in rats.
Life Sci
; 60(2): 101-6, 1997.
Article
en En
| MEDLINE
| ID: mdl-9000115
ABSTRACT
The pharmacokinetics of a new ASA-nitroderivative compound, NCX 4016 (ASA-NO2), was evaluated using an HPLC method. After single equimolar doses of ASA (35 mg kg(-1)) or ASA-NO2 (65 mg kg(-1)), no detectable levels of these compounds have been observed in rat plasma samples. SA peak levels were obtained at 3 h and 6 h after ASA and ASA-NO2 administration respectively. The elimination rate constants of SA were similar after ASA and ASA-NO2, suggesting a similar elimination phase of this metabolite in rats. From these data it is evident that ASA-NO2 is slowly metabolized in ASA, which is rapidly converted to SA.
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Bases de datos:
MEDLINE
Asunto principal:
Aspirina
Límite:
Animals
Idioma:
En
Revista:
Life Sci
Año:
1997
Tipo del documento:
Article
País de afiliación:
Italia