Somatic gene transfer approaches to manipulate neural networks.
J Neurosci Methods
; 71(1): 133-42, 1997 Jan.
Article
en En
| MEDLINE
| ID: mdl-9125382
ABSTRACT
Gene transfer methods can be exploited to create somatic mosaic tissues to elucidate gene product action in cells comprising a network. This article describes the evolution of approaches beginning from herpes amplicon vectors with constitutive gene expression to herpes vectors with regulated gene expression and concludes with the development of a combined germline/somatic gene transfer method that allows for highly versatile spatial and temporal control of in vivo gene expression. Where possible examples of each approach are provided. In addition, the advantages and limitations of the approaches are discussed.
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Bases de datos:
MEDLINE
Asunto principal:
Transfección
/
Red Nerviosa
Límite:
Animals
Idioma:
En
Revista:
J Neurosci Methods
Año:
1997
Tipo del documento:
Article
País de afiliación:
Estados Unidos