Phospholipid breakdown and choline release under hypoxic conditions: inhibition by bilobalide, a constituent of Ginkgo biloba.
Brain Res
; 755(2): 347-50, 1997 May 02.
Article
en En
| MEDLINE
| ID: mdl-9175905
ABSTRACT
A marked increase of choline release from rat hippocampal slices was observed when the slices were superfused with oxygen-free buffer, indicating hypoxia-induced hydrolysis of choline-containing phospholipids. This increase of choline release was suppressed by bilobalide, an ingredient of Ginkgo biloba, but not by a mixture of ginkgolides. The EC50 value for bilobalide was 0.38 microM. In ex vivo experiments, bilobalide also inhibited hypoxia-induced choline release when given p.o. in doses of 2-20 mg/kg 1 h prior to slice preparation. The half-maximum effect was observed with 6 mg/kg bilobalide. A similar effect was noted after p.o. administration of 200 mg/kg EGb 761, a ginkgo extract containing approximately 3% of bilobalide. We conclude that ginkgo extracts can suppress hypoxia-induced membrane breakdown in the brain, and that bilobalide is the active constituent for this effect.
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Bases de datos:
MEDLINE
Asunto principal:
Fosfolípidos
/
Extractos Vegetales
/
Hipoxia Encefálica
/
Colina
/
Ciclopentanos
/
Diterpenos
/
Furanos
/
Hipocampo
Tipo de estudio:
Risk_factors_studies
Límite:
Animals
Idioma:
En
Revista:
Brain Res
Año:
1997
Tipo del documento:
Article
País de afiliación:
Alemania