Cortisol response to d-fenfluramine in patients with obsessive-compulsive disorder and in healthy subjects: evidence for a gender-related effect.
Neuropsychobiology
; 36(1): 8-12, 1997.
Article
en En
| MEDLINE
| ID: mdl-9211437
ABSTRACT
In order to evaluate serotonergic function in obsessive-compulsive disorder (OCD), plasma cortisol response to d-fenfluramine (30 mg p.o.) was examined in 20 drug-free obsessive-compulsive patients (10 males and 10 females) and in 20 age- and sex-matched healthy subjects, under double-blind, placebo-controlled conditions. We found that (a) baseline plasma cortisol secretion was significantly increased in patients with OCD; (b) in healthy subjects, the cortisol response to d-fenfluramine was evident in women, but no in men; (c) plasma cortisol response to the serotonergic challenge did not differ between patients and controls, but it was significantly reduced in female patients as compared to healthy women. These results demonstrate a hyperactivity of the hypothalamo-pituitary-adrenal axis in obsessive-compulsive patients and suggest a dysfunction of 5-HT transmission in female patients.
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Bases de datos:
MEDLINE
Asunto principal:
Sistema Hipófiso-Suprarrenal
/
Hidrocortisona
/
Fenfluramina
/
Sistema Hipotálamo-Hipofisario
/
Trastorno Obsesivo Compulsivo
Tipo de estudio:
Clinical_trials
Límite:
Adolescent
/
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Neuropsychobiology
Año:
1997
Tipo del documento:
Article
País de afiliación:
Italia