Role of different neurotransmitter systems in the cholecystokinin octapeptide-induced anxiogenic response in rats.
Neuropeptides
; 31(3): 281-5, 1997 Jun.
Article
en En
| MEDLINE
| ID: mdl-9243526
ABSTRACT
The possible involvement of different neurotransmitter systems in the anxiogenic action of cholecystokinin octapeptide sulphate ester (CCK-8) was investigated in rats. Intracerebroventricularly (i.c.v.) administered CCK-8 induced an anxiogenic response in an elevated plus-maze test. Pretreatment with dopaminergic, muscarinergic acetylcholine receptor blockers and an opiate receptor antagonist blocked the anxiogenic response to CCK-8. The alpha and beta adrenoreceptor, the GABA receptor and the 5-hydroxytryptamine (5-HT) receptor blockers were not able to modulate the 'anxiogenic-like' effect of CCK-8. The results suggest that the anxiogenic effects of CCK-8 are mediated via different neurotransmitters and the anxiogenic action can be prevented by receptor blockers to these transmitters.
Buscar en Google
Bases de datos:
MEDLINE
Asunto principal:
Ansiedad
/
Sincalida
Límite:
Animals
Idioma:
En
Revista:
Neuropeptides
Año:
1997
Tipo del documento:
Article
País de afiliación:
Hungria