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Interleukin-6 secretion in mice is associated with reduced glucose-6-phosphatase and liver glycogen levels.
Metzger, S; Goldschmidt, N; Barash, V; Peretz, T; Drize, O; Shilyansky, J; Shiloni, E; Chajek-Shaul, T.
Afiliación
  • Metzger S; Division of Medicine, Hadassah University Hospital, Jerusalem, Israel.
Am J Physiol ; 273(2 Pt 1): E262-7, 1997 Aug.
Article en En | MEDLINE | ID: mdl-9277378
Mice bearing interleukin-6 (IL-6)-secreting tumor were used to study the chronic effect of IL-6 on carbohydrate metabolism. Mice were injected with allogeneic tumor cells transduced with the murine IL-6 gene. Serum IL-6 levels were correlated exponentially with tumor weight. Secretion of IL-6 from the developed tumors was associated with decreased food consumption, reduced body weight, and reduced blood glucose levels. Insulin levels did not change, and 2-deoxyglucose uptake was not affected in most tissues examined. A significant increase of 2-deoxyglucose uptake was measured in the liver. Glycogen content in the liver determined 0, 6, 12, and 18 days after tumor inoculation was 42, 23, 12, and 3 mg/g, respectively. The activity of phosphoenolpyruvate carboxykinase was not affected. The activity of glucose-6-phosphatase (G-6-Phase) determined 6, 12, and 18 days after tumor injection was 84, 70, and 50% of G-6-Pase activity in pair-fed mice bearing nonsecreting tumors, respectively. G-6-Pase mRNA levels were markedly reduced due to inhibition of G-6-Pase gene transcriptional rate.
Asunto(s)
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Bases de datos: MEDLINE Asunto principal: Interleucina-6 / Glucosa-6-Fosfatasa / Glucógeno / Hígado Tipo de estudio: Risk_factors_studies Límite: Animals Idioma: En Revista: Am J Physiol Año: 1997 Tipo del documento: Article País de afiliación: Israel
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Bases de datos: MEDLINE Asunto principal: Interleucina-6 / Glucosa-6-Fosfatasa / Glucógeno / Hígado Tipo de estudio: Risk_factors_studies Límite: Animals Idioma: En Revista: Am J Physiol Año: 1997 Tipo del documento: Article País de afiliación: Israel