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Comparison of the complete genomic sequence of the border disease virus, BD31, to other pestiviruses.
Ridpath, J F; Bolin, S R.
Afiliación
  • Ridpath JF; National Animal Disease Center, USDA, Agricultural Research Service, Ames, IA 50010, USA. jridpath@nadc.ars.usda.gov
Virus Res ; 50(2): 237-43, 1997 Aug.
Article en En | MEDLINE | ID: mdl-9282788
The genus Pestivirus is composed of hog cholera virus (HCV) [also known as classical swine fever virus (CSFV)], bovine viral diarrhea virus (BVDV), and border disease virus (BDV). Complete sequences have been published for HCV (or CSFV) and the two genotypes of BVDV (BVDV1 and BVDV2). In this study the complete sequence of the border disease virus (BDV), BD31, was determined. BD31 was isolated from a lamb with hairy shaker syndrome and is the BDV type virus offered by ATCC (ATCC VR-996). The genome was 12268 nucleotides long and had a single large open reading frame (ORF) beginning at nucleotide 357 and ending at nucleotide 12045. The sequence identity of the predicted amino acid sequence of BD31 and other published pestivirus sequences varied from 71% to 78%. Phylogenetic analysis of available complete genomic sequences segregated pestiviruses into two branches. One branch contained BD31 and HCV (or CSFV) isolates while the other branch contained BVDV1 and BVDV2 isolates. Pestiviruses from the same branch were similar in the length of the 5' and 3' untranslated regions (UTR). When complete genomic sequences were compared among BD31, HCV (or CSFV), BVDV1 and BVDV2, the highest sequence identity was observed in the 5' UTR. Within the ORF, the highest sequence identity was observed in the genomic region coding for the nonstructural viral polypeptide p80.
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Bases de datos: MEDLINE Asunto principal: Genoma Viral / Virus de la Enfermedad de la Frontera / Pestivirus Límite: Animals Idioma: En Revista: Virus Res Asunto de la revista: VIROLOGIA Año: 1997 Tipo del documento: Article País de afiliación: Estados Unidos
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Bases de datos: MEDLINE Asunto principal: Genoma Viral / Virus de la Enfermedad de la Frontera / Pestivirus Límite: Animals Idioma: En Revista: Virus Res Asunto de la revista: VIROLOGIA Año: 1997 Tipo del documento: Article País de afiliación: Estados Unidos