Ampullosporin, a new peptaibol-type antibiotic from Sepedonium ampullosporum HKI-0053 with neuroleptic activity in mice.

Ritzau, M; Heinze, S; Dornberger, K; Berg, A; Fleck, W; Schlegel, B; Härtl, A; Gräfe, U

Ritzau, M; Heinze, S; Dornberger, K; Berg, A; Fleck, W; Schlegel, B; Härtl, A; Gräfe, U.

Afiliación

Ritzau M; Hans-Knöll-Institute of Natural Products Research, Jena, Germany.

J Antibiot (Tokyo) ; 50(9): 722-8, 1997 Sep.

Article en En | MEDLINE | ID: mdl-9360615

ABSTRACT

ABSTRACT

Ampullosporin (I; Ac-Trp-Ala-Aib-Aib-Leu-Aib-Gln-Aib-Aib-Aib-Gln-Leu-Aib-Gln-Leuol) was isolated from the mycelium of Sepedonium ampullosporum as a new 15-membered peptaibol-type antibiotic. The structure was determined by mass spectrometric and two-dimensional NMR experiments. Ampullosporin displays narrow-spectrum antibacterial and antifungal activity, induces pigment formation by Phoma destructiva, causes hypothermia and decreased spontaneous locomotor activity in mice in dosages > 1 mg/kg.

Asunto(s)

Antibacterianos/aislamiento & purificación; Antibacterianos/farmacología; Antifúngicos/aislamiento & purificación; Antifúngicos/farmacología; Péptidos; Animales; Antibacterianos/química; Antifúngicos/química; Cromatografía Líquida de Alta Presión; Femenino; Masculino; Ratones; Pruebas de Sensibilidad Microbiana; Hongos Mitospóricos; Estructura Molecular; Peptaiboles

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Bases de datos: MEDLINE Asunto principal: Péptidos / Antibacterianos / Antifúngicos Límite: Animals Idioma: En Revista: J Antibiot (Tokyo) Año: 1997 Tipo del documento: Article País de afiliación: Alemania

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