Protease-protease inhibitor interactions in Sertoli cell-germ cell crosstalk.
Adv Exp Med Biol
; 424: 111-23, 1997.
Article
en En
| MEDLINE
| ID: mdl-9361776
ABSTRACT
Peritubular cells, Sertoli cells, and germ cells of the seminiferous tubule synthesize and secrete several proteases and protease inhibitors. Experimental evidence suggests that the complex network of proteolytic enzyme activity and their regulation by protease inhibitors play an important role in male reproduction. Interaction between protease and protease inhibitors seems to play an important role in remodeling and restructuring of the seminiferous tubule during spermatogenesis. Controlled proteolytic activity is also involved in the migration of germ cells from the basal compartment to the lumen of the seminiferous epithelium, and in the release of spermatids during spermiation. The recently reported occurrence of Sertoli cell membrane-associated proteases indicate the possible involvement of regulatory peptide systems within the testis. This view is supported by the detection of all components of one of these paracrine systems, the kallikrein-kinin system, in cells of the seminiferous tubule.
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Bases de datos:
MEDLINE
Asunto principal:
Inhibidores de Proteasas
/
Células de Sertoli
/
Espermatozoides
/
Metaloendopeptidasas
Límite:
Animals
/
Humans
/
Male
Idioma:
En
Revista:
Adv Exp Med Biol
Año:
1997
Tipo del documento:
Article
País de afiliación:
Alemania