Veno-occlusive disease-like hepatotoxicity in two children receiving chemotherapy for Wilms' tumor and clear cell sarcoma of kidney.
Pediatr Hematol Oncol
; 15(1): 85-9, 1998.
Article
en En
| MEDLINE
| ID: mdl-9509511
We report two pediatric cases who developed veno-occlusive disease-like hepatotoxicity while receiving chemotherapy for Wilms' tumor and clear cell sarcoma of kidney. The chemotherapeutics, including vincristine, actinomycin D, and epirubicin in case 1 and vincristine and actinomycin D in case 2, were given before the hepatotoxicity developed. Other possible causes of hepatotoxicity were excluded. Recovery was observed with supportive therapy after 2 and 1 weeks, respectively. After recovery, the children tolerated continued chemotherapy without any decrease in the doses of drugs. We conclude that vincristine and actinomycin D were the cause of this rare from of hepatotoxicity and that chemotherapy for the underlying malignant disease could be given safely after clinical recovery.
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Bases de datos:
MEDLINE
Asunto principal:
Enfermedad Veno-Oclusiva Hepática
/
Protocolos de Quimioterapia Combinada Antineoplásica
/
Sarcoma de Células Claras
/
Tumor de Wilms
/
Neoplasias Renales
/
Hígado
Tipo de estudio:
Diagnostic_studies
Límite:
Humans
/
Infant
/
Male
Idioma:
En
Revista:
Pediatr Hematol Oncol
Asunto de la revista:
HEMATOLOGIA
/
NEOPLASIAS
/
PEDIATRIA
Año:
1998
Tipo del documento:
Article
País de afiliación:
Turquía