Loss of heterozygosity for chromosome 1p in familial neuroblastoma.
Eur J Cancer
; 33(12): 1953-6, 1997 Oct.
Article
en En
| MEDLINE
| ID: mdl-9516831
ABSTRACT
Loss of heterozygosity (LOH) and deletion of chromosome 1p are very often found in sporadic neuroblastoma. Nevertheless, very few data are available concerning 1p LOH in familial neuroblastoma. Families with recurrent neuroblastoma are rare and analysis of chromosome 1p in these families might give useful information for identifying the putative neuroblastoma suppressor gene. We used combined cytogenetic and molecular techniques to study 1p LOH in two neuroblastoma families. Family M has 2 out of 3 children with neuroblastoma and family C has 2 children, 1 of whom has neuroblastoma and type 1 neurofibromatosis (NF1). All patients of both families showed tumour cells with chromosome 1p deletion (1pdel), but only the patient from family C also had MYCN gene amplification. In all cases the deleted chromosome 1 was of maternal origin.
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Bases de datos:
MEDLINE
Asunto principal:
Cromosomas Humanos Par 1
/
Pérdida de Heterocigocidad
/
Neoplasias Abdominales
/
Neuroblastoma
Tipo de estudio:
Prognostic_studies
Límite:
Child, preschool
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
Eur J Cancer
Año:
1997
Tipo del documento:
Article
País de afiliación:
Italia