Gastrointestinal tract as a major site of CD4+ T cell depletion and viral replication in SIV infection.
Science
; 280(5362): 427-31, 1998 Apr 17.
Article
en En
| MEDLINE
| ID: mdl-9545219
ABSTRACT
Human and simian immunodeficiency virus (HIV and SIV) replicate optimally in activated memory CD4(+) T cells, a cell type that is abundant in the intestine. SIV infection of rhesus monkeys resulted in profound and selective depletion of CD4+ T cells in the intestine within days of infection, before any such changes in peripheral lymphoid tissues. The loss of CD4+ T cells in the intestine occurred coincident with productive infection of large numbers of mononuclear cells at this site. The intestine appears to be a major target for SIV replication and the major site of CD4+ T cell loss in early SIV infection.
Buscar en Google
Bases de datos:
MEDLINE
Asunto principal:
Linfocitos T CD4-Positivos
/
Síndrome de Inmunodeficiencia Adquirida del Simio
/
Virus de la Inmunodeficiencia de los Simios
/
Colon
/
Intestino Delgado
Límite:
Animals
Idioma:
En
Revista:
Science
Año:
1998
Tipo del documento:
Article
País de afiliación:
Estados Unidos