pRB, p107 and p130 as transcriptional regulators: role in cell growth and differentiation.
Prog Cell Cycle Res
; 3: 157-69, 1997.
Article
en En
| MEDLINE
| ID: mdl-9580269
ABSTRACT
The mammalian cell cycle engine, which is composed of cyclin/CDK holoenzymes, controls the progression throughout the cell cycle by regulating, at least in part, the transcription of two types of genes genes whose protein products are required for DNA metabolism and genes whose protein products are involved in cell cycle control. Among the targets of cyclin/CDKs, there is a family of negative growth regulators collectively known as pocket proteins. This family of pocket proteins includes the product of the retinoblastoma tumor suppressor gene, pRB and the functionally and structurally related proteins p107 and p130. In this review, the mechanisms by which pocket proteins are thought to regulate cell growth and differentiation are discussed.
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Bases de datos:
MEDLINE
Asunto principal:
Fosfoproteínas
/
Proteínas Nucleares
/
Proteínas
/
Proteínas Portadoras
/
Diferenciación Celular
/
División Celular
/
Proteína de Retinoblastoma
/
Proteínas de Ciclo Celular
/
Proteínas de Unión al ADN
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Prog Cell Cycle Res
Año:
1997
Tipo del documento:
Article
País de afiliación:
Estados Unidos