Endogenous opioids and ATP-sensitive potassium channels are involved in the mediation of apomorphine-induced antinociception at the spinal level: a behavioral study in rats.
Brain Res Bull
; 46(3): 225-8, 1998 Jun.
Article
en En
| MEDLINE
| ID: mdl-9667815
ABSTRACT
The effects of intrathecally (i.t.) administered glibenclamide, a blocker of adenosine triphosphate-sensitive potassium (K(ATP)) channels, or naloxone on the antinociception produced by i.t. apomorphine or morphine were observed and analyzed in rats by tail-flick (TF) test. The results showed that (1) i.t. apomorphine produced a significant and dose-dependent antinociception, (2) the antinociception produced by i.t. apomorphine could be blocked dose-dependently by i.t. glibenclamide or naloxone, (3) the antinociception produced by i.t. morphine could also be blocked dose-dependently by i.t. glibenclamide. The results suggest that endogenous opioids and ATP-sensitive potassium channels might be involved in the mediation of apomorphine-induced antinociception at the spinal level.
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Bases de datos:
MEDLINE
Asunto principal:
Médula Espinal
/
Nociceptores
/
Endorfinas
/
Canales de Potasio
/
Apomorfina
/
Adenosina Trifosfato
/
Agonistas de Dopamina
Tipo de estudio:
Diagnostic_studies
Límite:
Animals
Idioma:
En
Revista:
Brain Res Bull
Año:
1998
Tipo del documento:
Article