Association of long variants of the dopamine D4 receptor exon 3 repeat polymorphism with Parkinson's disease.
Clin Genet
; 54(1): 33-8, 1998 Jul.
Article
en En
| MEDLINE
| ID: mdl-9727737
ABSTRACT
The dopamine D4 receptor (D4DR) has a highly polymorphic region in the third exon which has been associated with novelty seeking (NS) behavior. Due to the central position of dopamine and the documented low NS in Parkinson's disease (PD), the frequency of the exon 3 variants of D4DR in 95 PD patients and 47 controls was investigated. A significantly higher frequency of exon 3 alleles with six or more repeat units was found in the PD group (p = 0.039). This provides evidence that some forms of the highly polymorphic D4DR may represent a genetic susceptibility factor for PD.
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Bases de datos:
MEDLINE
Asunto principal:
Enfermedad de Parkinson
/
Polimorfismo Genético
/
Receptores de Dopamina D2
Tipo de estudio:
Observational_studies
/
Risk_factors_studies
Límite:
Adult
/
Aged
/
Aged80
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Clin Genet
Año:
1998
Tipo del documento:
Article
País de afiliación:
Estados Unidos