Local administration of L-703,081 using a composite polymeric stent reduces platelet deposition in canine coronary arteries.
Am J Cardiol
; 82(5): 673-5, A8, 1998 Sep 01.
Article
en En
| MEDLINE
| ID: mdl-9732901
ABSTRACT
We compared the effect on platelet deposition of the glycoprotein IIb/IIIa receptor antagonist L-703,081, administered locally via a drug delivery stent, with that of a standard metal stent in a canine coronary model. There was a significant reduction in platelet deposition using the L-703,081-impregnated stent compared with the bare metal stent. This study demonstrates an alternative route of delivery of GPIIb/IIIa antagonists with potential advantages over systemic administration.
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Bases de datos:
MEDLINE
Asunto principal:
Poliésteres
/
Inhibidores de Agregación Plaquetaria
/
Stents
/
Agregación Plaquetaria
/
Complejo GPIIb-IIIa de Glicoproteína Plaquetaria
/
Circulación Coronaria
/
Vasos Coronarios
Límite:
Animals
Idioma:
En
Revista:
Am J Cardiol
Año:
1998
Tipo del documento:
Article
País de afiliación:
Estados Unidos