Numbers and differentiation status of melanocytes in idiopathic guttate hypomelanosis.
J Cutan Pathol
; 25(7): 375-9, 1998 Aug.
Article
en En
| MEDLINE
| ID: mdl-9765023
ABSTRACT
The etiology and pathogenesis of idiopathic guttate hypomelanosis (IGH) are largely unknown. To investigate whether the pathologic alteration in IGH involves changes in melanocytic differentiation, cell number, or both, we studied nine lesions of IGH by immunoperoxidase, using monoclonal antibodies against the KIT receptor and a panel of melanocyte differentiation antigens (tyrosinase-related protein-1, tyrosinase, and gp100/pme117). In each case, compared with grossly normal non-lesional skin, IGH lesions showed markedly reduced numbers both of KIT+ cells and of cells expressing melanocyte differentiation antigens (p < 0.0001). Double immunofluorescence labeling of lesions revealed only scattered cells with a less-differentiated phenotype, i.e. cells positive for KIT but having low or undetectable TRP-1. These results indicate that the pathogenesis of IGH involves an absolute decrease in the number of melanocytes; a block in melanocyte differentiation does not appear to be a major component of the process.
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Bases de datos:
MEDLINE
Asunto principal:
Oxidorreductasas
/
Piel
/
Enfermedades de la Piel
/
Glicoproteínas de Membrana
/
Hipopigmentación
/
Melanocitos
Límite:
Adult
/
Humans
Idioma:
En
Revista:
J Cutan Pathol
Año:
1998
Tipo del documento:
Article
País de afiliación:
Estados Unidos