Analysis of 3p allelic losses in renal cell carcinomas: comparison with cytogenetic results.
Cancer Genet Cytogenet
; 107(2): 121-4, 1998 Dec.
Article
en En
| MEDLINE
| ID: mdl-9844606
ABSTRACT
We performed a study of loss of heterozygosity (LOH) at 3p by restriction fragment length polymorphism analysis in a series of 22 renal tumors. In 11 cases, molecular results could be compared with those of cytogenetic studies. The highest frequency of allelic losses at 3p was seen in clear cell non-papillary renal tumors, whereas none of the papillary renal cell carcinomas showed LOH at 3p. Allelic losses on 3p were found to be independent of tumor grade or stage or both. One case analyzed showed a discrepancy between cytogenetic and LOH studies. This tumor displayed rearrangements of chromosome 3 and no LOH at the c-RAF-1 (close to the Von Hippel Lindau gene) locus.
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Bases de datos:
MEDLINE
Asunto principal:
Cromosomas Humanos Par 3
/
Carcinoma de Células Renales
/
Pérdida de Heterocigocidad
/
Neoplasias Renales
Límite:
Humans
Idioma:
En
Revista:
Cancer Genet Cytogenet
Año:
1998
Tipo del documento:
Article
País de afiliación:
España