Adrenal angiotensin II type 1 and type 2 receptors in Cushing's and Conn's syndromes.
Mol Cell Endocrinol
; 144(1-2): 37-45, 1998 Sep 25.
Article
en En
| MEDLINE
| ID: mdl-9863625
ABSTRACT
Cushing's and Conn's syndromes are well recognised endocrine diseases, but the pathobiology of the tumors causing these disorders is unclear. In this study we examined AT1 and AT2 gene expression in adrenal adenomas of Cushing's and Conn's syndromes. AT1 and AT2 receptor mRNA, as well as alternatively spliced AT1 transcripts, were detected by RT-PCR using adjacent adrenal cortex tissue as controls. Whereas no consistent differences in AT1 mRNA were seen compared to control adrenal cortex, AT2 mRNA levels were significantly decreased in the adenomas of Cushing's and Conn's syndromes. No changes in alternative splicing of AT1 mRNA were observed in the adrenal tumors. The fact that no consistent changes were seen in AT1 mRNA or its splicing, whereas AT2 mRNA were reduced in both forms of hormone producing adrenal tumor suggests that the AT2 receptor, rather than the AT1 subtype, may be correlated with adrenal tumorigenesis.
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Bases de datos:
MEDLINE
Asunto principal:
Receptores de Angiotensina
/
Empalme Alternativo
/
Síndrome de Cushing
/
Hiperaldosteronismo
Límite:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Mol Cell Endocrinol
Año:
1998
Tipo del documento:
Article
País de afiliación:
Japón