Role of the retinoblastoma protein family, pRB, p107 and p130 in the negative control of cell growth.
Oncogene
; 17(25): 3365-83, 1998 Dec 24.
Article
en En
| MEDLINE
| ID: mdl-9916999
ABSTRACT
The retinoblastoma family of proteins, also known as pocket proteins, includes the product of the retinoblastoma susceptibility gene and the functionally and structurally related proteins p107 and p130. Pocket proteins control growth processes in many cell types, and this has been linked to the ability of pocket proteins to interact with a multitude of cellular proteins that regulate gene expression at various levels. By regulating gene expression, pocket proteins control cell cycle progression, cell cycle entry and exit, cell differentiation and apoptosis. This review will focus on the mechanisms of regulation of pocket proteins and how modulation of pocket protein levels and phosphorylation status regulate association with their cellular targets. The coordinated regulation of pocket proteins provides the cells with a competence mechanism for passage through certain cell growth and differentiation transitions.
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Bases de datos:
MEDLINE
Asunto principal:
Fosfoproteínas
/
Proteínas Nucleares
/
Proteínas
/
Proteínas Portadoras
/
Regulación de la Expresión Génica
/
Proteína de Retinoblastoma
/
Proteínas de Ciclo Celular
/
Proteínas de Unión al ADN
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Oncogene
Asunto de la revista:
BIOLOGIA MOLECULAR
/
NEOPLASIAS
Año:
1998
Tipo del documento:
Article
País de afiliación:
Estados Unidos