Detalhe da pesquisa
1.
Development of 1,5-diarylpyrazoles as EGFR/JNK-2 dual inhibitors: design, synthesis, moleecular docking, and bioactivity evaluation.
Bioorg Med Chem Lett
; 102: 129673, 2024 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-38408511
2.
A decade's overview of 2-aminothiophenes and their fused analogs as promising anticancer agents.
Arch Pharm (Weinheim)
; : e2300758, 2024 Mar 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-38442316
3.
Development and Assessment of 1,5-Diarylpyrazole/Oxime Hybrids Targeting EGFR and JNK-2 as Antiproliferative Agents: A Comprehensive Study through Synthesis, Molecular Docking, and Evaluation.
Molecules
; 28(18)2023 Sep 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-37764297
4.
New pyrimidine/thiazole hybrids endowed with analgesic, anti-inflammatory, and lower cardiotoxic activities: Design, synthesis, and COX-2/sEH dual inhibition.
Arch Pharm (Weinheim)
; 355(7): e2200024, 2022 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-35429006
5.
Design, synthesis, and biological evaluation of new pyrimidine-5-carbonitrile derivatives bearing 1,3-thiazole moiety as novel anti-inflammatory EGFR inhibitors with cardiac safety profile.
Bioorg Chem
; 111: 104890, 2021 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-33872924
6.
Design, synthesis, and antibacterial evaluation of new quinoline-1,3,4-oxadiazole and quinoline-1,2,4-triazole hybrids as potential inhibitors of DNA gyrase and topoisomerase IV.
Bioorg Chem
; 112: 104920, 2021 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-33910078
7.
Design and synthesis of pyrimidine-5-carbonitrile hybrids as COX-2 inhibitors: Anti-inflammatory activity, ulcerogenic liability, histopathological and docking studies.
Bioorg Chem
; 108: 104555, 2021 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-33376011
8.
Design and synthesis of new 1,6-dihydropyrimidin-2-thio derivatives targeting VEGFR-2: Molecular docking and antiproliferative evaluation.
Bioorg Chem
; 102: 104090, 2020 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-32683176
9.
Design, synthesis and biological evaluation of some new 1,3,4-thiadiazine-thiourea derivatives as potential antitumor agents against non-small cell lung cancer cells.
Bioorg Chem
; 93: 103323, 2019 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-31586713
10.
Towards anticancer fluoroquinolones: A review article.
Arch Pharm (Weinheim)
; 352(7): e1800376, 2019 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-31215674
11.
Synthesis, cyclooxygenase inhibition and anti-inflammatory evaluation of new 1,3,5-triaryl-4,5-dihydro-1H-pyrazole derivatives possessing methanesulphonyl pharmacophore.
J Enzyme Inhib Med Chem
; 31(6): 1545-55, 2016 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-27072288
12.
Design and synthesis of some substituted thiazolo[3,2-a]pyrimidine derivatives of potential biological activities.
Saudi Pharm J
; 24(2): 119-32, 2016 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-27013904
13.
JNK signaling as a target for anticancer therapy.
Pharmacol Rep
; 73(2): 405-434, 2021 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-33710509
14.
Molecular hybrids: A five-year survey on structures of multiple targeted hybrids of protein kinase inhibitors for cancer therapy.
Eur J Med Chem
; 225: 113768, 2021 Dec 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-34450497
15.
Synthesis, antitumor, antibacterial and urease inhibitory evaluation of new piperazinyl N-4 carbamoyl functionalized ciprofloxacin derivatives.
Pharmacol Rep
; 73(3): 891-906, 2021 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-33389728
16.
Design, synthesis and anticancer activity of new monastrol analogues bearing 1,3,4-oxadiazole moiety.
Eur J Med Chem
; 138: 140-151, 2017 Sep 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-28667871