RESUMO
Current treatment of chronic wounds has been critically limited by various factors, including bacterial infection, biofilm formation, impaired angiogenesis, and prolonged inflammation. Addressing these challenges, we developed a multifunctional wound dressing-based three-pronged approach for accelerating wound healing. The multifunctional wound dressing, composed of nanofibers, functional nanoparticles, natural biopolymers, and selected protein and peptide, can target multiple endogenous repair mechanisms and represents a promising alternative to current wound healing products.
Assuntos
Anexina A1/administração & dosagem , Anti-Inflamatórios/administração & dosagem , Bandagens , Diabetes Mellitus Experimental/complicações , Proteínas Relacionadas à Folistatina/administração & dosagem , Peptídeos/administração & dosagem , Infecções Estafilocócicas/complicações , Infecções Estafilocócicas/tratamento farmacológico , Staphylococcus aureus/efeitos dos fármacos , Ferida Cirúrgica/complicações , Ferida Cirúrgica/tratamento farmacológico , Cicatrização/efeitos dos fármacos , Infecção dos Ferimentos/complicações , Infecção dos Ferimentos/tratamento farmacológico , Células 3T3 , Animais , Materiais Biocompatíveis/administração & dosagem , Biopolímeros/química , Sobrevivência Celular/efeitos dos fármacos , Diabetes Mellitus Experimental/induzido quimicamente , Células HaCaT , Humanos , Nanopartículas Magnéticas de Óxido de Ferro/química , Masculino , Teste de Materiais/métodos , Camundongos , Nanofibras/química , Ratos , Ratos Wistar , Infecções Estafilocócicas/microbiologia , Resultado do Tratamento , Infecção dos Ferimentos/microbiologiaRESUMO
New N-monosubstituted diaminomaleonitrile-based azo-azomethine dyes have been synthesized in order to develop colorimetric sensors for detection of biologically important anions in aqueous media. Importantly, the reported sensor decorated with strong electron-withdrawing group can detect inorganic fluoride in water even at 0.037 ppm level, which is lower than WHO permissible level (below 1 ppm). Successfully, the prepared dyes were used for qualitative and quantitative detection of inorganic fluoride in toothpaste and mouthwash. The anion recognition mechanism was also investigated by detailed UV-Vis and (1)H NMR experiments. The detailed (1)H NMR experiments corroborated that anion recognition is based on the deprotonation phenomenon.