Therapeutic Potential of Nitrogen-Doped Rutin-Bound Glucose Carbon Dots for Alzheimer's Disease.

The blood-brain barrier (BBB) prevents the use of many drugs for the treatment of neurological disorders. Recently, nitrogen-doped carbon dots (NCDs) have emerged as promising nanocarriers to cross BBB. The primary focus of our study was to evaluate the effectiveness of NCDs for the symptomatic treatment of Alzheimer's disease (AD). In this study, we developed and characterized NCDs bound to rutin, a flavonoid with known benefits for AD. Despite its benefits, the transportation of rutin via NCDs for AD therapy has not been explored previously. We characterized the particles using FTIR and UV-visible spectroscopy followed by atomic force microscopy. Once the design was optimized and validated, we performed in vivo testing via a hemolytic assay to optimize the dosage. Preliminary in vitro testing was performed in AlCl3-induced rat models of AD whereby a single dose of 10 mg/kg NCDs-rutin was administered intraperitoneally. Interestingly, this single dose of 10 mg/kg NCDs-rutin produced the same behavioral effects as 50 mg/kg rutin administered intraperitoneally for 1 month. Similarly, histological and biomarker profiles (SOD2 and TLR4) also presented significant protective effects of NCDs-rutin against neuronal loss, inflammation, and oxidative stress. Hence, NCDs-rutin are a promising approach for the treatment of neurological diseases.

Harnessing the power of artificial intelligence and robotics impact on attaining competitive advantage for sustainable development in hospitals with conclusions for future research approaches.

Artificial intelligence (AI) and robotics have emerged as game-changing technologies with the potential to revolutionize the healthcare industry. In the context of hospitals, their integration holds the promise of not only improving patient care but also driving competitive advantage and fostering sustainable development. This review paper aims to explore and evaluate the impact of AI and robotics applications on attaining competitive advantage and promoting sustainable development in hospitals, examines the current landscape of AI and robotics adoption in healthcare settings and delve into their specific applications within hospitals, including AI-assisted diagnosis, robotic surgery, patient monitoring, and data analytics. A key finding is the insufficient use of KI to date in terms of promoting sustainable development in hospitals. Furthermore, attempts to analyze the potential benefits and challenges associated with these technologies in terms of enhancing patient outcomes, operational efficiency, cost savings, and differentiation from competitors. Drawing upon a comprehensive review of the existing literature and case studies, this paper provides valuable insights into the transformative potential of AI and robotics in hospitals.