Detalhe da pesquisa
1.
High-Dose Acetaminophen with Concurrent CYP2E1 Inhibition Has Profound Anticancer Activity without Liver Toxicity.
J Pharmacol Exp Ther
; 388(1): 209-217, 2024 01 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-37918853
2.
The thrombopoietin mimetic JNJ-26366821 reduces the late injury and accelerates the onset of liver recovery after acetaminophen-induced liver injury in mice.
Arch Toxicol
; 98(6): 1843-1858, 2024 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-38551724
3.
Nrf2 as a therapeutic target in acetaminophen hepatotoxicity: A case study with sulforaphane.
J Biochem Mol Toxicol
; 37(12): e23505, 2023 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-37598316
4.
Interruption of bile acid uptake by hepatocytes after acetaminophen overdose ameliorates hepatotoxicity.
J Hepatol
; 77(1): 71-83, 2022 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-35131407
5.
Comparing N-acetylcysteine and 4-methylpyrazole as antidotes for acetaminophen overdose.
Arch Toxicol
; 96(2): 453-465, 2022 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-34978586
6.
Delayed administration of N-acetylcysteine blunts recovery after an acetaminophen overdose unlike 4-methylpyrazole.
Arch Toxicol
; 95(10): 3377-3391, 2021 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-34420083
7.
Impaired protein adduct removal following repeat administration of subtoxic doses of acetaminophen enhances liver injury in fed mice.
Arch Toxicol
; 95(4): 1463-1473, 2021 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-33458793
8.
4-methylpyrazole protects against acetaminophen-induced acute kidney injury.
Toxicol Appl Pharmacol
; 409: 115317, 2020 12 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-33157119
9.
Mice deficient in pyruvate dehydrogenase kinase 4 are protected against acetaminophen-induced hepatotoxicity.
Toxicol Appl Pharmacol
; 387: 114849, 2020 01 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-31809757
10.
Pleiotropic Role of p53 in Injury and Liver Regeneration after Acetaminophen Overdose.
Am J Pathol
; 188(6): 1406-1418, 2018 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-29654721
11.
Protective effect of genetic deletion of pannexin1 in experimental mouse models of acute and chronic liver disease.
Biochim Biophys Acta Mol Basis Dis
; 1864(3): 819-830, 2018 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-29246445
12.
Spatial analysis of renal acetaminophen metabolism and its modulation by 4-methylpyrazole with DESI mass spectrometry imaging.
Toxicol Sci
; 198(2): 328-346, 2024 Mar 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-38291912
13.
Clinically relevant therapeutic approaches against acetaminophen hepatotoxicity and acute liver failure.
Biochem Pharmacol
; : 116056, 2024 Feb 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-38346541
14.
Lack of mitochondrial Cyp2E1 drives acetaminophen-induced ER stress-mediated apoptosis in mouse and human kidneys: Inhibition by 4-methylpyrazole but not N-acetylcysteine.
Toxicology
; 500: 153692, 2023 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-38042273
15.
Pre- and Post-Sexual Maturity Liver-specific ERα Knockout Does Not Impact Hepatic Mitochondrial Function.
J Endocr Soc
; 7(6): bvad053, 2023 May 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-37197409
16.
Hepatocyte-specific deletion of small heterodimer partner protects mice against acetaminophen-induced hepatotoxicity via activation of Nrf2.
Toxicol Sci
; 197(1): 53-68, 2023 12 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-37792503
17.
Desorption Electrospray Ionization Mass Spectrometry Imaging Allows Spatial Localization of Changes in Acetaminophen Metabolism in the Liver after Intervention with 4-Methylpyrazole.
J Am Soc Mass Spectrom
; 33(11): 2094-2107, 2022 Nov 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-36223142
18.
Mitochondrial protein adduct and superoxide generation are prerequisites for early activation of c-jun N-terminal kinase within the cytosol after an acetaminophen overdose in mice.
Toxicol Lett
; 338: 21-31, 2021 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33290831
19.
Recommendations for the use of the acetaminophen hepatotoxicity model for mechanistic studies and how to avoid common pitfalls.
Acta Pharm Sin B
; 11(12): 3740-3755, 2021 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-35024303
20.
Liver-specific deletion of mechanistic target of rapamycin does not protect against acetaminophen-induced liver injury in mice.
Liver Res
; 5(2): 79-87, 2021 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-34504721