Detalhe da pesquisa
1.
6-Methylpurine derived sugar modified nucleosides: Synthesis and evaluation of their substrate activity with purine nucleoside phosphorylases.
Bioorg Chem
; 65: 9-16, 2016 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-26745284
2.
Role of methylthioadenosine/S-adenosylhomocysteine nucleosidase in Vibrio cholerae cellular communication and biofilm development.
Biochem Biophys Res Commun
; 461(1): 65-9, 2015 May 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-25849889
3.
The crystal structure of Streptococcus pyogenes uridine phosphorylase reveals a distinct subfamily of nucleoside phosphorylases.
Biochemistry
; 50(30): 6549-58, 2011 Aug 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-21707079
4.
Structure of grouper iridovirus purine nucleoside phosphorylase.
Acta Crystallogr D Biol Crystallogr
; 66(Pt 2): 155-62, 2010 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-20124695
5.
The use of Trichomonas vaginalis purine nucleoside phosphorylase to activate fludarabine in the treatment of solid tumors.
Cancer Chemother Pharmacol
; 85(3): 573-583, 2020 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-31915968
6.
Excellent in vivo bystander activity of fludarabine phosphate against human glioma xenografts that express the escherichia coli purine nucleoside phosphorylase gene.
Cancer Res
; 64(18): 6610-5, 2004 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-15374975
7.
6-Methylpurine derived sugar modified nucleosides: Synthesis and in vivo antitumor activity in D54 tumor expressing M64V-Escherichia coli purine nucleoside phosphorylase.
Eur J Med Chem
; 108: 616-622, 2016 Jan 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-26724729
8.
Antibiotic-mediated chemoprotection enhances adaptation of E. coli PNP for herpes simplex virus-based glioma therapy.
Hum Gene Ther
; 16(3): 339-47, 2005 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-15812229
9.
Designer gene therapy using an Escherichia coli purine nucleoside phosphorylase/prodrug system.
Chem Biol
; 10(12): 1173-81, 2003 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-14700625
10.
Design and evaluation of 5'-modified nucleoside analogs as prodrugs for an E. coli purine nucleoside phosphorylase mutant.
Nucleosides Nucleotides Nucleic Acids
; 24(5-7): 387-92, 2005.
Artigo
em Inglês
| MEDLINE | ID: mdl-16247956
11.
Antitumor activity of 2-fluoro-2'-deoxyadenosine against tumors that express Escherichia coli purine nucleoside phosphorylase.
Cancer Gene Ther
; 10(1): 23-9, 2003 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-12489025
12.
Metabolism of 2-methyladenosine in Mycobacterium tuberculosis.
Tuberculosis (Edinb)
; 84(5): 327-36, 2004.
Artigo
em Inglês
| MEDLINE | ID: mdl-15207808
13.
Selective metalation of 6-methylpurines: synthesis of 6-fluoromethylpurines and related nucleosides.
Nucleosides Nucleotides Nucleic Acids
; 22(5-8): 747-9, 2003.
Artigo
em Inglês
| MEDLINE | ID: mdl-14565269
14.
Novel DNA methyltransferase-1 (DNMT1) depleting anticancer nucleosides, 4'-thio-2'-deoxycytidine and 5-aza-4'-thio-2'-deoxycytidine.
Cancer Chemother Pharmacol
; 74(2): 291-302, 2014 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-24908436
15.
In vivo antitumor activity of intratumoral fludarabine phosphate in refractory tumors expressing E. coli purine nucleoside phosphorylase.
Cancer Chemother Pharmacol
; 70(2): 321-9, 2012 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-22760227
16.
Synthesis and evaluation of the substrate activity of C-6 substituted purine ribosides with E. coli purine nucleoside phosphorylase: palladium mediated cross-coupling of organozinc halides with 6-chloropurine nucleosides.
Eur J Med Chem
; 47(1): 167-74, 2012 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-22112758
17.
Regioselective metalation of 6-methylpurines: synthesis of fluoromethyl purines and related nucleosides for suicide gene therapy of cancer.
Nucleosides Nucleotides Nucleic Acids
; 28(5): 642-56, 2009 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-20183607
18.
Evaluation of 3-deaza-adenosine analogues as ligands for adenosine kinase and inhibitors of Mycobacterium tuberculosis growth.
J Antimicrob Chemother
; 59(1): 118-21, 2007 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-17085766
19.
Structural basis for substrate specificity of Escherichia coli purine nucleoside phosphorylase.
J Biol Chem
; 278(47): 47110-8, 2003 Nov 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-12937174
20.
A long-acting suicide gene toxin, 6-methylpurine, inhibits slow growing tumors after a single administration.
J Pharmacol Exp Ther
; 304(3): 1280-4, 2003 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-12604707